Evolution-driven attenuation of alphaviruses highlights key glycoprotein determinants regulating viral infectivity and dissemination
First Stapleford Lab CHIKV dissemination paper! Gaby, Bruno, and Margarita identify a network of molecular interactions that modulate CHIKV infectivity and dissemination. (https://www.ncbi.nlm.nih.gov/pubmed/31291581)
Chikungunya virus vaccine candidates with decreased mutational robustness are attenuated in vivo and have compromised transmissibility.
Collaboration with the Vignuzzi lab at Institut Pasteur, Paris, to develop novel vaccine strategies for arboviruses. (https://www.ncbi.nlm.nih.gov/pubmed/31270226)
Atovaquone Inhibits Arbovirus Replication through the Depletion of Intracellular Nucleotides.
First paper from the Stapleford Lab! Angelica Kottkamp defines the antiviral mechanism of the antiparasitic drug atovaquone. (https://www.ncbi.nlm.nih.gov/pubmed/30894466)
Chikungunya virus evolution following a large 3'UTR deletion results in host-specific molecular changes in protein-coding regions.
Collaboration with Paul Turner's lab at Yale University to understand the evolution of the chikungunya virus 3'UTR. (https://www.ncbi.nlm.nih.gov/pubmed/29942653)